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Contributed by : Dr. Andrew Eik Hock Tan
Nuclear Physician


About Nanomedicine

Nanomedicine is a type of nanotechnology that focuses on medical intervention at the molecular level to repair tissues and treat diseases. This field combines expertise in medicine, mathematics, biology, engineering, chemistry, and computer science to make equipment for human use.

With nanomedicine, scientists have been able to assemble proteins that locate cancer and drugs that destroy tumors into nanomaterials the size of a hair strand.

One of the medical applications of nanotechnology is the use of nanoparticles to deliver drugs, heat, light or other substances to specific types of cells (such as cancer cells) … This technology reduces the damage to healthy body cells, and The disease can be detected earlier.

Nanotherapy, as a branch of nanomedicine, uses nanoparticles to deliver drugs to target locations in the body to treat diseases. This process is what we often call ” targeted therapy ” . SIRT is one type of targeted therapy.

About SIRT

Selective internal radiation therapy ( SIRT ) is a treatment method for liver cancer that cannot be surgically removed.

SIRT is a minimally invasive day surgery; and is only suitable for liver cancer patients whose liver is the only or main focus.

Before using SIRT as a treatment plan, a simple blood test is required to confirm whether the patient’s liver function is suitable for SIRT .

If deemed suitable, the treatment will be carried out by a medical team, including an interventional radiologist, a nuclear medicine physician, and a hepatologist, as well as other experts trained in radiotherapy.

Selective internal radiation therapy

contributed by Dr Andrew Tan in English

SIRT is a cancer treatment method that directly injects tiny radioactive examples into the hepatic artery to treat liver cancer. Since 2008 since the implementation in Singapore, specializing in cancer therapy this minimally invasive, showing excellent efficacy and safety compared with traditional chemotherapy with fewer side effects.

This therapy is suitable for patients who cannot undergo radical surgery, such as primary liver cancer (such as hepatocellular carcinoma and cholangiocarcinoma) or liver metastatic disease (such as colon cancer).

SIRT can effectively control the disease and in many cases has improved the cancer to the extent that it can be operated on. In order to improve the safety and effectiveness of treatment, it is necessary to assess whether the patient is suitable for SIRT and calculate the required radiation dose before SIRT treatment . Each treatment is a personalized treatment for the specific conditions of different patients.

Singapore is a pioneer in  artery specific partition modelling dosimetry  , and has matured and mastered this advanced technology for tumor-specific calculation of radiation dose.